Trapping individual cell types in the mouse brain

first_imgShare on Twitter LinkedIn Share on Facebook The complexity of the human brain depends upon the many thousands of individual types of nerve cells it contains. Even the much simpler mouse brain probably contains 10,000 or more different neuronal cell types. Brandeis scientists Yasu Shima, Sacha Nelson and colleagues report in the journal eLife on a new approach for genetically identifying and manipulating these cell types.Cells in the brain have different functions and therefore express different genes. Important instructions for which genes to express, in which cell types, lie not only in the genes themselves, but in small pieces of DNA called enhancers found in the large spaces between genes.The Brandeis group has found a way to highjack these instructions to express other artificial genes in particular cell types in the mouse brain. Some of these artificially expressed genes (also called transgenes) simply make the cells fluorescent so they can be seen under the microscope. Pinterestcenter_img Email Share Other transgenes are master regulators that can be used to turn on or off any other gene of interest. This will allow scientists to activate or deactivate the cells to see how they alter behavior, or to study the function of specific genes by altering them only in some cell types without altering them everywhere in the body.In addition to developing the approach, the Brandeis group created a resource of over 150 strains of mice in which different brain cell types can be studied.last_img read more

‘Emma’ brings matchmaking play to Aurora

first_imgYou know that one kind yet ultimately misguided person in the group that plays ‘The Game of Life’ with their friends? Well, Harriet Smith knows just about that. No, she’s not on the latest ‘Dr. Phil,’ she’s the focus of Emma Woodhouse’s machinations of love in the aptly titled musical ‘Emma.’ An adaption of Jane Austen’s book, Emma is all witty, beautiful, and spoiled. Naturally, she sets her meddling mind to matchmake for others, vowing to never fall in love herself.Of course, this only leads to her falling in love.Shows are Friday and Saturday, 7:30 P.M. and Sunday at 2:30 P.M., now until Aug. 18. Monday show at 7:30 P.M., July 29. Tickets range from $16-$32. Vintage Theatre,1468 Dayton St. Vintagetheatre.org. 303-856-7830.last_img read more