Sleep may strengthen long-term memories in the immune system

first_imgLinkedIn Studies in humans have shown that long-term increases in memory T cells are associated with deep slow-wave sleep on the nights after vaccination. Taken together, the findings support the view that slow-wave sleep contributes to the formation of long-term memories of abstract, generalized information, which leads to adaptive behavioral and immunological responses. The obvious implication is that sleep deprivation could put your body at risk.“If we didn’t sleep, then the immune system might focus on the wrong parts of the pathogen,” Born says. “For example, many viruses can easily mutate some parts of their proteins to escape from immune responses. If too few antigen-recognizing cells [the cells that present the fragments to T cells] are available, then they might all be needed to fight off the pathogen. In addition to this, there is evidence that the hormones released during sleep benefit the crosstalk between antigen-presenting and antigen-recognizing cells, and some of these important hormones could be lacking without sleep.”Born says that future research should examine what information is selected during sleep for storage in long-term memory, and how this selection is achieved. In the end, this research could have important clinical implications.“In order to design effective vaccines against HIV, malaria, and tuberculosis, which are based on immunological memory, the correct memory model must be available,” Born says. “It is our hope that by comparing the concepts of neuronal and immunological memory, a model of immunological memory can be developed which integrates the available experimental data and serves as a helpful basis for vaccine development.” Share Email More than a century ago, scientists demonstrated that sleep supports the retention of memories of facts and events. Later studies have shown that slow-wave sleep, often referred to as deep sleep, is important for transforming fragile, recently formed memories into stable, long-term memories. Now, in an Opinion article published September 29 in Trends in Neurosciences, part of a special issue on Neuroimmunology, researchers propose that deep sleep may also strengthen immunological memories of previously encountered pathogens.“While it has been known for a long time that sleep supports long-term memory formation in the psychological domain, the idea that long-term memory formation is a function of sleep effective in all organismic systems is in our view entirely new,” says senior author Jan Born of the University of Tuebingen. “We consider our approach toward a unifying concept of biological long-term memory formation, in which sleep plays a critical role, a new development in sleep research and memory research.”The immune system “remembers” an encounter with a bacteria or virus by collecting fragments from the bug to create memory T cells, which last for months or years and help the body recognize a previous infection and quickly respond. These memory T cells appear to abstract “gist information” about the pathogens, as only T cells that store information about the tiniest fragments ever elicit a response. The selection of gist information allows memory T cells to detect new pathogens that are similar, but not identical, to previously encountered bacteria or viruses.center_img Pinterest Share on Facebook Share on Twitterlast_img read more

Lear Elects Matt Simoncini CEO; Bob Rossiter to Step Down After 40 Years of Service

first_imgSOUTHFIELD, Mich. — Lear Corp. has announced that Matt Simoncini, senior vice president and chief financial officer, has been elected CEO and president effective Sept. 1. Simoncini also will join Lear’s board of directors on Sept. 1. In his new role, Simoncini will be responsible for the strategic direction and operational leadership of the company. AdvertisementClick Here to Read MoreAdvertisement Simoncini succeeds Bob Rossiter, who will step down as CEO, president and a director of Lear, also on Sept. 1. Rossiter will remain in an advisory role until May 2012 to assist with the transition. “Bob has been an exceptional leader and a driving force in building Lear Corp. into a world-class global enterprise with nearly $14 billion in annual sales and 200 facilities in 35 countries supported by 93,000 employees,” said Henry D. G. Wallace, non-executive chairman. “Bob fostered a culture of the highest business integrity, industry-leading customer service and support of the communities where Lear does business. On behalf of Lear’s Board of Directors and its customers, suppliers, employees and shareholders, I want to sincerely thank Bob for his dedicated service.”   “I have been involved in the CEO succession process with the board and I am very supportive of the selection of Matt Simoncini to succeed me,” said Rossiter. “I have worked closely with Matt over the years and I am confident that I am turning over Lear to very capable hands.” “Matt has worked at Lear and its predecessor companies for 15 years in positions of increasing responsibility, including a tour of duty in Europe. He is passionate about the business and he is an inspirational leader. Matt is very knowledgeable about Lear’s global operations, customers, products and employees, and he exemplifies the company’s core values of integrity, quality and customer service. He successfully led the company’s financial restructuring and has been instrumental in repositioning Lear for long-term success. Matt has been an exceptional chief financial officer, has led the company’s strategic planning efforts and he is now ready to assume the role as chief executive officer,” added Wallace.Advertisement Currently, Simoncini is senior vice president and chief financial officer of Lear Corp., a role he has held since September 2007. As SVP and CFO, he is responsible for Lear’s global finance operations, including external financial reporting, corporate business planning and analysis, corporate strategy and business development as well as information technology activities worldwide. In August 2006, he was named senior vice president of global finance and chief accounting officer where he was responsible for Lear’s worldwide operational finance, accounting and financial reporting. Prior to that, he was vice president of global finance, a position he had held since June 2004. Simoncini also served as Lear’s vice president of finance – Europe, as well as holding the vice president of Finance position for Lear’s Electrical & Electronics business and DaimlerChrysler division. Simoncini joined Lear from United Technologies Automotive (UTA) in April 1996 as director of finance for the Motors Division, with responsibility for the financial activities of the business unit. At the time of Lear’s acquisition of UTA, Simoncini was director of financial planning and analysis. Previous to UTA, Simoncini held financial and manufacturing positions with Varity Kelsey Hayes and Horizon Enterprises, including chief financial officer of Kelsey Hayes’ European Operations. Simoncini began his career at Touche Ross and is a certified public accountant.Advertisement “Lear is truly a great company, and I am honored to have been elected as CEO. Bob is leaving the company in a very strong competitive position, with positive earnings momentum, the best team in the industry and significant cash resources to fund future growth. I look forward to continuing to deliver superior quality and customer service and to sustaining Lear’s positive momentum,” Simoncini commented. Born and raised in Detroit, Simoncini earned a bachelor’s degree from Wayne State University and is a member of the Michigan Association of Certified Public Accountants. In addition to his responsibilities at Lear, he is a trustee for VIP Mentoring and also a member of the United Way for Southeastern Michigan Campaign Committee.last_img read more

See The Signs

first_imgThe Suffolk County Historical Society in Riverhead presents a special free artists’ reception on Saturday, January 18, at 1 PM featuring “Urban/Suburban” in the Gish Gallery. The show, which will run through February 29, features street photography by Neil Scholl. It depicts the bustling streets of New York City and rural stills across the North Fork.Scholl is a professor emeritus of New York Institute of Technology, where he taught photography and graphic design. His work has been exhibited along Long Island, including the Montauk Lighthouse Museum and Water Mill Museum.“Though we are primarily a history museum, we do enjoy occasionally incorporating modern artistic themes that evoke nostalgic memories of life in Suffolk County, and Neil Scholl’s street photography work does just that,” said Suffolk County Historical Society’s executive director, Victoria Berger.“His photography, captured with a skillful eye, was curated to conjure memories of some of our favorite roadside ‘landmarks’ of the North Fork, going as far back as the ’60s, juxtaposed against images of similar sites in more concrete settings. The results make you better appreciate the tranquility of our region, while striking a very nostalgic chord for those who may recognize the local landscapes portrayed in his work,” she said. The Suffolk County Historical Society Museum is located at 300 W. Main Street in Riverhead. Learn more at Sharelast_img read more

Linde to build Thailand liquid carbon dioxide plant

first_imgGet instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270. Subscribelast_img

Rotarex to exhibit latest valves at SEMICON

first_imgGet instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270. Subscribelast_img

Fugro to Conduct Hydrographic Surveys in Papua New Guinea

first_imgFugro has been awarded a total of six contracts by the National Maritime Safety Authority (NMSA) to provide hydrographic surveys in Papua New Guinea .The surveys will be conducted utilizing a combination of Fugro’s airborne LiDAR bathymetry (ALB) and multibeam echo sounder (MBES) sensors.In deeper waters the surveys will be performed by a vessel and Fugro will also conduct a comprehensive tides campaign throughout the survey area.The contracts are part of the Asian Development Bank-funded Maritime Waterways Safety Project that aims to improve the safety and efficiency of the country’s international and national shipping in coastal areas and waterways.The project is expected to contribute to capacity development in the country, which has over 5,000 kilometers of coastline.last_img read more

NDA president to give WDS welcome

first_imgChris Godek, the recently appointed president of the USA’s National Demolition Association (NDA) will welcome delegates to this year’s World Demolition Summit (WDS) in Boston.#*#*Show Fullscreen*#*# Chris GodekChris, who was sworn in during the NDA’s Demolition Rockies event at Aurora, Colorado in March, will give a short welcoming speech to the 400-plus industry professionals expected at the showpiece event taking place in October.He becomes the third successive NDA president to take an active role at the WDS, following Peter Banks, who shared conference chairing duties at Miami in 2016 with then vice-president Scott Knightly, and Scott himself – who was a conference speaker at London the following year after succeeding Peter in the presidency.Demolition & Recycling International is organising the summit in co-operation with the NDA and we are delighted that Chris will say a few words at the start of the event, which is returning to North America after a gap of three years.The recent Europe-based events in London and Dublin were hugely popular with American and Canadian delegates, with well received conference presentations from the likes of Brandenburg’s Dennis McGarel and Brent Willson of Dustless Technologies. There were also popular award winners in the shape of companies such as Ferma Corporation, Adamo Group and the overall winner Kiewit/Manson.This year’s event starts with a networking drinks reception on the evening of Wednesday October 23, followed the next day by a conference during the daytime and awards dinner in the evening.Headline sponsor of the event is Volvo Construction Equipment.For more details of the WDS, please visit www.demolitionsummit.comlast_img read more

Can public sector land disposal really provide the answer to the UK’s housing crisis?

first_imgGet your free guest access  SIGN UP TODAY Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our community To continue enjoying, sign up for free guest accessExisting subscriber? LOGIN Subscribe now for unlimited access Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to industry news as it happensBreaking, daily and weekly e-newsletterslast_img read more

PI solicitor helped client who wanted to hide damages from husband

first_imgAn experienced personal injury lawyer has agreed to be struck off after drafting a letter to help a client conceal from her husband the extent of a damages settlement. Geoffrey Hart, a former director with Midlands firm Ward & Rider, had secured damages of £48,000 after costs for his client in 2017. But, during a telephone discussion, the client advised Hart she would be telling her husband the claim settled for £30,000 and asked him to prepare a letter confirming the lower amount.Hart then wrote to state damages were £30,000 and broke down the elements of the claim. He wrote a further letter two weeks later referring to the £30,000 figure.The Solicitors Disciplinary Tribunal heard that the client, who was a family friend of Hart’s wife, had told him she wanted to keep some of her own damages because her husband was controlling and would decide how the money was spent.Hart submitted that he became ‘very emotional’ after learning the client had gone through tragic events in her personal life similar to those he was experiencing at the time, and he acted out of character in drafting the false letter.A clinical psychologist report confirmed that Hart made a mistake while experiencing psychological difficulties and some associated impairment in cognitive processing – namely judgement and reasoning.Hart, a solicitor for 21 years, made no attempt to conceal the relevant letters and upon realising the seriousness of the matter he pressed his employer to recall the letter. He was reported to the SRA by his firm and resigned shortly after. The false letter was not shown to the client’s husband or anyone else.The tribunal heard that Hart also admitted sending an email to his wife, a solicitor, which included personal information about another client who had suffered a personal injury. The email was to provide his wife with a precedent document for her own legal practice.Hart and the SRA agreed on a joint outcome that he be struck off and pay £9,000 costs.last_img read more

Browns at Rams Wednesday Injury Report

first_imgFULL PARTICIPATION IN PRACTICE DID NOT PARTICIPATE IN PRACTICE ST. LOUIS RAMS WednesdayQB Johnny Manziel (right elbow) Practice Report CLEVELAND BROWNS WednesdayTE Gary Barnidge (ankle), LB Tank Carder (shoulder), DE John Hughes (knee), WR Marlon Moore (hamstring), LB Nate Orchard (groin), DT Danny Shelton (knee) Matt Loede LIMITED PARTICIPATION IN PRACTICE WednesdayS Tashaun Gipson (ankle), CB Joe Haden (concussion, finger), TE Rob Housler (hamstring), LB Craig Robertson (ankle), DE Randy Starks (not injury related), T Joe Thomas (not injury related) Practice Report The Browns and Rams took the practice field for the first time today in prep for Sunday’s 1pm showdown at the Edward Jones Dome. Practice was not yet wrapped up for St.Louis in time for the report, but the Browns did release their report.The three biggest names for the Browns were safety Tashaun Gipson, cornerback Joe Haden and LB Craig Robertson all were not on the practice field today with injuries.Here’s the complete practice report for the game from the NFL. Related TopicsBrownsJoe HadenNFL Week 7Rams WednesdayPractice Not Complete Matt Loede has been a part of the Cleveland Sports Media for over 21 years, with experience covering Major League Baseball, National Basketball Association, the National Football League and even high school and college events. He has been a part of the Cleveland Indians coverage since the opening of Jacobs/Progressive Field in 1994, and spent two and a half years covering the team for 92.3 The Fan, and covers them daily for Associated Press Radio. You can follow Matt on Twitter HERE.last_img read more